Ghate P.S., Vacharasin J.M., Ward J.A., Nowling D., Kay V., Cowen M.H., Lawlor M.K., McCord M., Xu H., Carmona E., Cheon S.H., Chukwurah E., Walla M., Lizarraga S.B. The Warburg micro syndrome protein RAB3GAP1 modulates neuronal morphogenesis and interacts with axon elongation end ER-Golgi trafficking factors. Neurobiology of Disease. 2023 June 28. https://doi.org/10.1016/j.nbd.2023.106215. PMID: 37385458
Ritchie F.D., Lizarraga S.B. The role of histone methyltransferases in neurocognitive disorders associated with brain size abnormalities. Front Neurosci. 2023 Feb 10;17:989109. doi: 10.3389/fnins.2023.989109. PMID: 36845425; PMCID: PMC9950662
Leung C.S., Rosenzweig S. J., Yoon B., Marinelli N.A., Hollingsworth E.W., Maguire A.M., Cowen M.H., Schmidt M., Imitola J., Gamsiz Uzun E.D., Lizarraga S.B. Dysregulation of the chromatin environment leads to differential alternative splicing as a mechanism of disease in a human model of autism spectrum disorder. Hum Mol Genet. 2023 Jan 9:ddad002. doi: 10.1093/hmg/ddad002. Epub ahead of print. PMID: 36621967
Cheon S., Culver A.M., Bagnell A.M., Ritchie F.D., Vacharasin J.M., McCord M.M., Papendorp C.M., Chukwurah E., Smith A.J., Cowen M.H., Moreland T.A., Ghate P.S., Davis S.W., Liu J.S., Lizarraga S.B. Counteracting epigenetic mechanisms regulate the structural development of neuronal circuitry in human neurons. Mol Psych 27, 2291-2303 (2022). https://doi.org/10.1038/s41380-022-01474-1. PMID: 35210569; PMCID: PMC9133078.
Lizarraga S.B., Maguire A.M., Ma L., van Dyck L.I., Wu Q., Ouyang Q., Kavanaugh B.C., Nagda D., Livi L.L., Pescosolido M.F., Schmidt M., Alabi S., Cowen M.H., Brito-Vargas P., Hoffman-Kim D., Gamsiz Uzun E.D., Schlessinger A., Jones R.N., Morrow E.M. (2021). Human neurons from Christianson syndrome iPSCs reveal allele-specific responses to rescue strategies. Sci Transl Med. Feb 10;13 (580) PMID: 33568516
Cui B.C., Sikirzhytski V., Aksenova M., Lucius M.D., Levon G.H., Mack Z.T., Pollack C., Odhiambo D., Broude E., Lizarraga S.B., Wyatt M.D., Shtutman M. (2020). Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly. Biochem Pharmacol. 2020 Dec;182:114280. doi: 10.1016/j.bcp.2020.114280. Epub 2020 Oct 10. PMID: 33049245; PMCID: PMC7686075.
Chukwurah E., Osmundsen A., Davis S.W., & Lizarraga S.B. (2019). All Together Now: Modelling the interaction of Neural with non-neural systems using organoid models.Frontiers in Neuroscience.
Aksenova M., Sybrandt J., Cui B., Sikirzhytsiki V., Ji H., Odhiambo D., Lucius M.D., Turner J.R., Broude E., Peña E., Lizarraga S.,Zhu J., Safro I., Wyatt M.D., & Shtutman M. (2019). Inhibition of Dead Box RNA Helicase 3 prevents HIV-1 Tat and Cocaine-induced neurotoxicity by targeting microglia activation. Journal of Neuroimmune Pharmacology
Xu M., Ouyang Q., Gong J., Pescosolido M.F., Pruett B.S., Mishra S., Schmidt M., Jones R.N., Gamsiz Uzun E.D., Lizarraga S.B., Morrow E.M.. (2018). Mixed Neurodevelopmental and Neurodegenerative Pathology in Nhe6-null mouse model of Christianson Syndrome. eNeuro. PMID:29349289
Hollingsworth E.W., Vaughn J.E., Orack J.C., Skinner C., Khouri J., Lizarraga S.B., Hester M.E., Watanabe F., Kosik K.S., Imitola J. (2017). iPhemap: an atlas of phenotype to genotype relationships of human iPSC models of neurological diseases. EMBO Mol Med. PMID 2905130
Ouyang Q., Nakayama T., Baytas O., Davidson S.M., Yang C., Schmidt M., Lizarraga S.B., Mishra S., Ei-Quessny M., Niaz S., Gul Butt M., Imran Murtaza S., Javed A., Chaundry H.R., Vaughan D.J., Hill R.S., Parlow J.N., Yoo S.Y., Lam A.N., Nasir R., Al-Saffar M., Barkovich A.J., Schwede M., Nagpal S., Rajab A., DeBerardinis R.J., Housman D.E., Mochida G.H., Morrow E.M.. (2016). Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features. Proc Natl Acad Sci pii: 201609221. PMID; 27601654
Lizarraga S.B. and Morrow E.M. Understanding the role of SK2 in Angelman Syndrome. Cell Reports. 12 (3)359-360. (2015)
Manzini C.M., Xiong L., Shaheen R., Tambunan D.E., Di Constanzo S., Mitisalis V., Tischfield D.J., Cinquino A., Ghaziuddin M., Christian M., Jian Q., Laurent S., Nanjiani Z.A., Rasheed S., Hill, R.S., Lizarraga S.B., Gleason D., Sabbagh D., Salih M.A., Alkuraya F.S., Walsh C.A. CC2D1A Regulates Human Intellectual and Social Function as well as NF-kB Signaling Homeostasis. Cell Reports. 8: 1-9 (2014).
Ouyang Q*, Lizarraga S.B.*, Schmidtt M., Yang U., Gong J., Ellisor D., Kauer J.A., Morrow E.M. Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development. Neuron. 80(1):97-112 (2013) . (This work was the cover art; highlighted by commentary in same issue in Neuron; chosen as Editors’ Choice at Science Signaling)*These authors contributed equally to this work
Lizarraga S.B.,Coser K.R., Sabbagh M, Morrow E.M. (2012) Methods for study of neuronal morphogenesis: Ex-vivo RNAi electroporation in embryonic murine cerebral cortex. J Vis Exp. 2012 May 18;(63):e3621.
Lizarraga SB, Margossian SP, Harris MH, Campagna DR, Han AP, Blevins S, Mudbhary R, Barker JE, Walsh CA, Fleming MD (2010). Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development. Jun;137(11):1907-17.
Sepp KJ, Hong P, Lizarraga SB, Liu JS, Mejia LA, Walsh CA, Perrimon N. (2008). Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet. Jul 4;4(7):e1000111.
Bond J, Roberts E, Springell K, Lizarraga SB, Scott S, Higgins J, Hampshire DJ, Morrison EE, Leal GF, Silva EO, Costa SM, Baralle D, Raponi M, Karbani G, Rashid Y, Jafri H, Bennett C, Corry P, Walsh CA, Woods CG. (2005). A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. Nat Genet. Apr;37(4):353-5.
O'Brien LL, Albee AJ, Liu L, Tao W, Dobrzyn P, Lizarraga SB, Wiese C. (2005). The Xenopus TACC homologue, maskin, functions in mitotic spindle assembly. Mol Biol Cell Jun;16(6):2836-47.
Lizarraga SB, Zheng Y, Wilde AR. (2002). Characterization of the effect of RanGTP on the microtubule cytoskeleton in GTPase protocols: The Ras superfamily. Methods Mol Biol. 189:247-60. Edited by E. J.Manser and T. Leung, Humana Press Inc. Totowa NJ.
Wilde A*, Lizarraga SB*, Zhang L, Wiese C, Gliksman NR, Walczak CE, Zheng Y. (2001). Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol. Mar;3(3):221-7. *both authors contributed equally to this work
Gunawardane RN,Lizarraga SB, Wiese C, Wilde A, Zheng Y (2000). Gamma-tubulin complexes and their role in microtubule nucleation in centrosome in cell replication and early development. Curr Top Dev Biol. 49:55-73
Pre-prints
Sofia B. Lizarraga, Abbie M. Maguire, Li Ma, Laura I. van Dyck, Qing Wu, DipalNagda, Liane L. Livi, Matthew F. Pescosolido, Michael Schmidt, Shanique Alabi, Mara H. Cowen, Paul Brito-Vargas, Diane Hoffman-Kim, Ece D. Gamsiz Uzun, AvnerSchlessinger, Richard N. Jones, Eric M. Morrow. Human neurons from Christianson syndrome iPSCs reveal allele-specific responses to rescue strategies. bioRxiv 444232; doi: https://doi.org/10.1101/444232