In Press

Vacharasin J.M., Ward J.A., McCord M.M., Cox K., Imitola J., Lizarraga S.B. Neuroimmune mechanisms in autism etiology - untangling a complex problem using human cellular models. Oxf Open Neurosci. 2024 Feb22;3:kvae003. doi: 10.1093/oons/kvae003. eCollection 2024  DOI: https://doi.org/10.1093/oons/kvae003. PMID: 38665176. 

Jhanji M., York E.M., Lizarraga S.B. The power of human stem cell-based systems in the study of neurodevelopmental disorders. Curr Opin Neurobiol. 2024 Sep 17. 89:102916. doi: 10.1016/j.conb.2024.102916. Online ahead of print. DOI: https://doi.org/10.1016/j.conb.2024.102916. PMID: 39293245.

Ghate P.S., Vacharasin J.M., Ward J.A., Nowling D., Kay V., Cowen M.H., Lawlor M.K., McCord M., Xu H., Carmona E., Cheon S.H., Chukwurah E., Walla M., Lizarraga S.B. The Warburg micro syndrome protein RAB3GAP1 modulates neuronal morphogenesis and interacts with axon elongation end ER-Golgi trafficking factors. Neurobiology of Disease. 2023 June 28. DOI: https://doi.org/10.1016/j.nbd.2023.106215. PMID: 37385458.

Ritchie F.D., Lizarraga S.B. The role of histone methyltransferases in neurocognitive disorders associated with brain size abnormalities. Front Neurosci. 2023 Feb 10;17:989109. DOI: https://doi.org/10.3389/fnins.2023.989109. PMID: 36845425; PMCID: PMC9950662.

Leung C.S., Rosenzweig S. J., Yoon B., Marinelli N.A., Hollingsworth E.W., Maguire A.M., Cowen M.H., Schmidt M., Imitola J., Gamsiz Uzun E.D., Lizarraga S.B. Dysregulation of the chromatin environment leads to differential alternative splicing as a mechanism of disease in a human model of autism spectrum disorder. Hum Mol Genet. 2023 Jan 9:ddad002. DOI: https://doi.org/10.1093/hmg/ddad002. Epub ahead of print. PMID: 36621967.

Cheon S., Culver A.M., Bagnell A.M., Ritchie F.D., Vacharasin J.M., McCord M.M., Papendorp C.M., Chukwurah E., Smith A.J., Cowen M.H., Moreland T.A., Ghate P.S., Davis S.W., Liu J.S., Lizarraga S.B. Counteracting epigenetic mechanisms regulate the structural development of neuronal circuitry in human neurons. Mol Psych 27, 2291-2303 (2022). DOI: https://doi.org/10.1038/s41380-022-01474-1. PMID: 35210569; PMCID: PMC9133078.

Lizarraga S.B., Maguire A.M., Ma L.,  van Dyck L.I., Wu Q., Ouyang Q., Kavanaugh B.C., Nagda D.,  Livi L.L., Pescosolido M.F., Schmidt M., Alabi S., Cowen M.H., Brito-Vargas P., Hoffman-Kim D., Gamsiz Uzun E.D., Schlessinger A., Jones R.N., Morrow E.M. (2021). Human neurons from Christianson syndrome iPSCs reveal allele-specific responses to rescue strategies. Sci Transl Med. Feb 10;13 (580) DOI: 10.1126/scitranslmed.aaw0682. PMID: 33568516.

Cui B.C., Sikirzhytski V., Aksenova M., Lucius M.D., Levon G.H., Mack Z.T., Pollack C., Odhiambo D., Broude E., Lizarraga S.B., Wyatt M.D., Shtutman M. (2020). Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly. Biochem Pharmacol. 2020 Dec;182:114280. DOI: https://doi.org/10.1016/j.bcp.2020.114280. Epub 2020 Oct 10. PMID: 33049245; PMCID: PMC7686075.

Chukwurah E., Osmundsen A., Davis S.W., & Lizarraga S.B. (2019). All Together Now: Modelling the interaction of Neural with non-neural systems using organoid models. Frontiers in Neuroscience. DOI: https://doi.org/10.3389/fnins.2019.00582​.
 
Aksenova M., Sybrandt J., Cui B., Sikirzhytsiki V., Ji H., Odhiambo D., Lucius M.D., Turner J.R., Broude E., Peña E., Lizarraga S., Zhu J., Safro I., Wyatt M.D., & Shtutman M. (2019). Inhibition of Dead Box RNA Helicase 3 prevents HIV-1 Tat and Cocaine-induced neurotoxicity by targeting microglia activation. Journal of Neuroimmune Pharmacology. DOI: https://doi.org/10.1007/s11481-019-09885-8.

Xu M., Ouyang Q., Gong J., Pescosolido M.F., Pruett B.S., Mishra S., Schmidt M., Jones R.N., Gamsiz Uzun E.D., Lizarraga S.B., Morrow E.M.. (2018). Mixed Neurodevelopmental and Neurodegenerative Pathology in Nhe6-null mouse model of Christianson Syndrome. eNeuro. DOI: https://doi.org/10.1523/ENEURO.0388-17.2017. PMID:29349289.

Hollingsworth E.W., Vaughn J.E., Orack J.C., Skinner C., Khouri J., Lizarraga S.B., Hester M.E., Watanabe F., Kosik K.S., Imitola J. (2017). iPhemap: an atlas of phenotype to genotype relationships of human iPSC models of neurological diseases. EMBO Mol Med. PMID 2905130. DOI: https://doi.org/10.15252/emmm.201708191.

Ouyang Q., Nakayama T., Baytas O., Davidson S.M., Yang C., Schmidt M., Lizarraga S.B., Mishra S., Ei-Quessny M., Niaz S., Gul Butt M., Imran Murtaza S., Javed A., Chaundry H.R., Vaughan D.J., Hill R.S., Parlow J.N., Yoo S.Y., Lam A.N., Nasir R., Al-Saffar M., Barkovich A.J., Schwede M., Nagpal S., Rajab A., DeBerardinis R.J., Housman D.E., Mochida G.H., Morrow E.M.. (2016). Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features. Proc Natl Acad Sci pii: 201609221. DOI: https://doi.org/10.1073/pnas.1609221113. PMID: 27601654.

Lizarraga S.B. and Morrow E.M. Uncovering a role for SK2 in Angelman Syndrome. Cell Reports. 12 (3)359-360. (2015). DOI: 10.1016/j.celrep.2015.07.009.

Manzini C.M., Xiong L., Shaheen R., Tambunan D.E., Di Constanzo S., Mitisalis V., Tischfield D.J., Cinquino A., Ghaziuddin M., Christian M., Jian Q., Laurent S., Nanjiani Z.A., Rasheed S., Hill, R.S., Lizarraga S.B., Gleason D., Sabbagh D., Salih M.A., Alkuraya F.S., Walsh C.A. CC2D1A Regulates Human Intellectual and Social Function as well as NF-kB Signaling Homeostasis. Cell Reports. 8: 1-9 (2014). DOI: 10.1016/j.celrep.2014.06.039.

Ouyang Q*, Lizarraga S.B.*, Schmidtt M., Yang U., Gong J., Ellisor D., Kauer J.A., Morrow E.M. Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development. Neuron. 80(1):97-112 (2013) . (This work was the cover art; highlighted by commentary in same issue in Neuron; chosen as Editors’ Choice at Science Signaling) DOI: 10.1016/j.neuron.2013.07.043. *These authors contributed equally to this work

Lizarraga S.B., Coser K.R., Sabbagh M, Morrow E.M. (2012). Methods for study of neuronal morphogenesis: Ex-vivo RNAi electroporation in embryonic murine cerebral cortex. J Vis Exp. 2012 May 18;(63):e3621. DOI: https://dx.doi.org/10.3791/3621​. PMID: 22643694.

Lizarraga S.B., Margossian S.P., Harris M.H., Campagna D.R., Han A.P., Blevins S., Mudbhary R., Barker J.E., Walsh C.A., Fleming M.D. (2010). Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development. Jun;137(11):1907-17. https://doi.org/10.1242/dev.040410.

Sepp K.J., Hong P., Lizarraga S.B., Liu J.S., Mejia L.A., Walsh C.A., Perrimon N. (2008). Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet. Jul 4;4(7):e1000111. https://doi.org/10.1371/journal.pgen.1000111.

Bond J., Roberts E., Springell K., Lizarraga S.B., Scott S., Higgins J., Hampshire D.J., Morrison E.E., Leal G.F., Silva E.O., Costa S.M., Baralle D., Raponi M., Karbani G., Rashid Y., Jafri H., Bennett C., Corry P., Walsh C.A., Woods C.G. (2005). A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. Nat Genet. Apr;37(4):353-5. https://doi.org/10.1038/ng1539.

O'Brien L.L., Albee A.J., Liu L., Tao W., Dobrzyn P., Lizarraga S.B., Wiese C. (2005). The Xenopus TACC homologue, maskin, functions in mitotic spindle assembly. Mol Biol Cell Jun;16(6):2836-47. https://doi.org/10.1091/mbc.e04-10-0926.

Lizarraga S.B., Zheng Y., Wilde A.R. (2002).  Characterization of the effect of RanGTP on the microtubule cytoskeleton in GTPase protocols: The Ras superfamily. Methods Mol Biol. 189:247-60. Edited by E. J.Manser and T. Leung, Humana Press Inc. Totowa NJ.  https://doi.org/10.1385/1-59259-281-3:247.

Wilde A.*, Lizarraga S.B.*, Zhang L., Wiese C., Gliksman N.R., Walczak C.E., Zheng Y. (2001).  Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol. Mar;3(3):221-7.  https://doi.org/10.1038/35060000.  *both authors contributed equally to this work

Gunawardane R.N., Lizarraga S.B., Wiese C., Wilde A., Zheng Y. (1999). Gamma-tubulin complexes and their role in microtubule nucleation. Curr Top Dev Biol. 49:55-73. DOI: https://doi.org/10.1016/S0070-2153(99)49004-0.


Pre-prints 

Megha Jhanji, Colleen L Krall, Alexis Guevara, Brian Yoon, Sajish Mathew, Luigi Boccuto, & Sofia Lizarraga (2024). The intersection of inflammation and DNA damage as a novel axis underlying the pathogenesis of autism spectrum disorders. bioRxiv, 2024-12. DOI: https://doi.org/10.1101/2024.12.11.627854.

Jhanji, M., Ward, J. A., Leung, C. S., Krall, C. L., Ritchie, F. D., Vestergaard, K., Yoon B., Amin K.M., Berto S., Liu J., & Lizarraga, S. B. (2024). Dynamic Regulation Of The Chromatin Environment By ASH1L Modulates Human Neuronal Structure And Function. bioRxiv, 2024-12. DOI: https://doi.org/10.1101/2024.12.02.625500​.

Cheon, S. H., Ritchie, F. D., Vacharasin, J. M., Marinelli, N., Cheatle, C., McCord, M. M., Cox, K., & Lizarraga, S. B. (2021). Overcoming the effect of ASH1L haploinsufficiency on stem cells amenability to genome editing and differentiation into the neuronal lineage–a technical report. bioRxiv, 2021-09. DOI: https://doi.org/10.1101/2021.09.27.461943.

Sofia B. Lizarraga, Abbie M. Maguire, Li Ma, Laura I. van Dyck, Qing Wu, DipalNagda, Liane L. Livi, Matthew F. Pescosolido, Michael Schmidt, Shanique Alabi, Mara H. Cowen, Paul Brito-Vargas, Diane Hoffman-Kim, Ece D. Gamsiz Uzun, AvnerSchlessinger, Richard N. Jones, Eric M. Morrow. Human neurons from Christianson syndrome iPSCs reveal allele-specific responses to rescue strategies. bioRxiv 444232; DOI: https://doi.org/10.1101/444232.